產品屬性：
產品名稱 | Tenuazonic Acid |
規格 | 1mg、10mg、25mg |
貨號 | EY-01Y9543 |
Cas No.: 610-88-8
別名: N/A
化學名: 3-acetyl-1,5-dihydro-4-hydroxy-5S-[(1S)-1-methylpropyl]-2H-pyrrol-2-one, monocopper salt
分子式: C10H14NO3 ? 1/2Cu
分子量: 228.0
溶解度: DMF: 30 mg/ml ; DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml; DMSO: 20 mg/ml; Ethanol: 20 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Tenuazonic acid is one of the major Alternaria mycotoxins commonly found as a natural contaminant in food (LD50 = 548 μg/egg in the chicken embryo toxicity assay).1 Tenuazonic acid contamination has been linked to esophageal cancer in human populations at risk of high exposure. Mice fed 100 mg/kg/day tenuazonic acid orally for 10 months developed precancerous lesions on the esophageal mucosa.2 Microscopic analysis of mucosal epithelial cells from these tenuazonic acid-treated animals reveal pyknosis and marked pleomorphisms in the nuclei, chromatin granulation and increased chromatin mass, irregularities in nuclear contours, and vacuolization in nucleoplasms.2
Reference
1. Griffin, G.F., and Chu, F.S. Toxicity of the Alternaria metabolites alternariol, alternariol methyl ether, altenuene, and tenuazonic acid in the chicken embryo assay Applied and Environmental Microbiology 46(6), 1420-1422 (1983).2. Yekeler, H., Bitmis, K., Oz?elik, N., et al. Analysis of toxic effects of Alternaria toxins on esophagus of mice by light and electron microscopy Toxicologic Pathology 29, 492-497 (2001).
特別提醒公司產品僅供科研使用
