產品屬性：
產品名稱 | Podophyllotoxin-d6 |
規格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y9593 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C22H16D6O8
分子量: 420.4
溶解度: Acetonitrile: soluble,DMF: soluble,DMSO: soluble,Ethanol: soluble,Methanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Podophyllotoxin-d6 is intended for use as an internal standard for the quantification of podophyllotoxin and picropodophyllotoxin by GC- or LC-MS. Podophyllotoxin is a lignan that has been found in Podophyllum and has diverse biological activities.1,2,3,4,5 It inhibits polymerization of isolated chicken brain tubulin (IC50 = 0.6 μM) and induces mitotic arrest at the G2/M phase in CCRF CEM lymphoblastic leukemia cells when used at concentrations ranging from 0.01 to 5 μg/ml.2,3 Podophyllotoxin (5 μM) is protective against herpes simplex virus 1 (HSV-1) infection in Vero cells.4 It inhibits the proliferation of several diffuse large B cell lymphoma (DLBCL) cell lines (IC50s = 0.0098-0.017 μM).5 Podophyllotoxin is a starting material in the semisynthesis of the anticancer compounds etoposide and teniposide .6 Formulations containing podophyllotoxin have been used in the treatment of external genital warts.1.Imbert, T.F.Discovery of podophyllotoxinsBiochimie80(3)207-222(1998)
2.Loike, J.D., Brewer, C.F., Sternlicht, H., et al.Structure-activity study of the inhibition of microtubule assembly in vitro by podophyllotoxin and its congenersCancer Res.38(9)2688-2693(1978)
3.Krishan, A., Paika, K., and Frei, E., IIICytofluorometric studies on the action of podophyllotoxin and epipodophyllotoxins (VM-26, VP-16-213) on the cell cycle traverse of human lymphoblastsJ. Cell Biol.66(3)521-530(1975)
4.Hammonds, T.R., Denyer, S.P., Jackson, D.E., et al.Studies to show that with podophyllotoxin the early replicative stages of herpes simplex virus type 1 depend upon functional cytoplasmic microtubulesJ. Med. Microbiol.45(3)167-172(1996)
5.Str?mberg, T., Feng, X., Delforoush, M., et al.Picropodophyllin inhibits proliferation and survival of diffuse large B-cell lymphoma cellsMed. Oncol.32(7)188(2015)
6.Xu, H., Lv, M., and Tian, X.A review on hemisynthesis, biosynthesis, biological activities, mode of action, and structure-activity relationship of podophyllotoxins: 2003-2007Curr. Med. Chem.16(3)327-349(2009)
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