產品屬性：
產品名稱 | Vapreotide (trifluoroacetate salt) |
規格 | 500μg、1mg |
貨號 | EY-01Y9562 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C57H70N12O9S2?XCF3COOH
分子量: 1131.4
溶解度: Water: 1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Vapreotide is a peptide neurokinin-1 receptor (NK1) antagonist and analog of somatostatin (IC50 = 330 nM in a radioligand binding assay). It inhibits increases in vascular permeability stimulated by substance P in a concentration-dependent manner in isolated guinea pig trachea and main bronchi. Vapreotide (8 nmol per animal) reduces substance P-induced biting and scratching in mice. It increases reaction time to heat stimuli in the hot plate and tail flick tests when administered at a dose of 512 μg/kg, indicating antinociceptive activity in mice. Vapreotide reduces plasma growth hormone (GH) increases induced by phenobarbital , morphine , and chlorpromazine , hypoglycemia-induced glucagon elevation, and glucose-induced insulin secretion in rats. It also decreases tumor weight and volume in a hamster model of pancreatic ductal adenocarcinoma and suppresses tumor growth and reduces GH secretion in SK-ES-1 and MNNG/HOS osteosarcoma mouse xenograft models.
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