產品屬性：

Cas No.: 1015856-57-1

別名: N/A

化學名: N/A

分子式: C16H13D5FN3O3

分子量: 324.4

溶解度: Chloroform: slightly,DMSO: slightly, heated

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Norfloxacin-d5 is intended for use as an internal standard for the quantification of norfloxacin by GC- or LC-MS. Norfloxacin is a fluoroquinolone antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria (MICs = 4 and 1 μg/ml for S. aureus and P. aeruginosa, respectively).1 It also inhibits the growth S. pseudintermedius, S. aureus, E. coli, Pasturella, and S. canis isolates from dogs (mean MIC50s = 0.25, 1, 0.03, 1, and 1 μg/ml, respectively).2 Topical administration of norfloxacin (0.1% v/v) reduces corneal ulcer size in a rabbit model of P. aeruginosa corneal infection. It also prevents encrusted cystitis in bladder and increases survival in a rat model of Corynebacterium group D2 infection when administered at a dose of 80 mg/kg per day.3 Formulations containing norfloxacin have been used to treat urinary tract and gynecological infections.1.Darrell, R.W., Modak, S.M., and Fox, C.L., Jr.Norfloxacin and silver norfloxacin in the treatment of Pseudomonas corneal ulcer in the rabbit.Trans. Am. Opthalmol. Soc.8275-91(1984)2.Awji, E.G., Damte, D., Lee, S.-J., et al.The in vitro activity of 15 antimicrobial agents against bacterial isolates from dogsJ. Vet. Med. Sci.74(8)1091-1094(2012)3.Soriano, F., Rodriguez-Tudela, J.L., Castilla, C., et al.Treatment of encrusted cystitis caused by Corynebacterium group D2 with norfloxacin, ciprofloxacin, and teicoplanin in an experimental model in ratsAntimicrob. Agents Chemother.35(12)2587-2590(1991)
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