產品屬性：

Cas No.: 550-33-4

別名: N/A

化學名: N/A

分子式: C10H12N4O4

分子量: 252.2

溶解度: DMF: 15 mg/ml,DMSO: 30 mg/ml,PBS (pH 7.2): 1 mg/ml

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Nebularine is a purine ribonucleoside and an adenosine analog that has been found in L. nebularis and has diverse biological activities.1,2,3,4,5 It reduces herpes simplex virus 1 (HSV-1) viral plaque formation in Vero cells (IC50 = 0.6 μM) and is active against M. phlei, M. avium, M. tuberculosis, and B. abortus.1,2 Nebularine (10 and 100 μM) is cytotoxic to COS-7 cells and induces pyknosis in mouse sarcoma 180 cells and mouse embryonic skin explants in a concentration-dependent manner.3,4 It inhibits root growth of wheat seedlings when used at concentrations ranging from 0.1 to 2 mM.2 Nebularine also inhibits adenosine deaminase (Ki = 16 μM).51.Julián-Ortiz, J.V., Gálvez, J., Mu?oz-Collado, C., et al.Virtual combinatorial syntheses and computational screening of new potential anti-herpes compoundsJ. Med. Chem.42(17)3308-3314(1999)2.Brown, E.G., and Konuk, M.Plant cytotoxicity of nebularine (purine riboside)Phytochemistry37(6)1589-1592(1994)3.Tkacz, K., Cioroch, M., Skladanowski, A.C., et al.The cytotoxic effect of purine riboside on COS-7 cellsPurine and Pyrimidine Metabolism in Man X. Advances in Experimental Medicine and Biology486355-359(2000)4.Biesele, J.J., Slautterback, C., and Margolis, M.Unsubstituted purine and its riboside as toxic antimetabolites in mouse tissue culturesCancer8(1)87-96(1955)5.Shewach, D.S., Krawczyk, S.H., Acevedo, O.L., et al.Inhibition of adenosine deaminase by azapurine ribonucleosidesBiochem. Pharmacol.44(9)1697-1700(1992)"
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