產品屬性：

Cas No.: 1279033-32-7

別名: N/A

化學名: N/A

分子式: C13H12D8N6O4.HCl

分子量: 368.8

溶解度: DMF: 10 mg/ml,DMSO: 3 mg/ml,Ethanol: Insolule,PBS (pH 7.2): 10 mg/ml

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

L-Valacyclovir-d8 is intended for use as an internal standard for the quantification of L-valacyclovir by GC- or LC-MS. L-Valacyclovir is an L-valyl prodrug form of the antiviral guanosine analog acyclovir . L-Valacyclovir inhibits herpes simplex virus type 1 (HSV-1) replication (IC50 = 0.84 μM in Vero cells).1 It is more potent than the stereoisomer D-valacyclovir but less potent than acyclovir in vitro, however, it is rapidly converted to acyclovir in vivo.2 Formulations containing L-valacyclovir have been used in the treatment of HSV-1 infections.1.Beauchamp, L.M., Orr, G.F., de Miranda, P., et al.Amino acid ester prodrugs of acyclovirAntivir. Chem. Chemother.3(3)157-164(1992)2.Beutner, K.R.Valacyclovir: A review of its antiviral activity, pharmacokinetic properties, and clinical efficacyAntiviral Res.28(4)281-290(1995)
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