產品屬性：
產品名稱 | NPD-1335 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y10201 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C28H29N3O3
分子量: 455.55
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
NPD1335 is a Trypanosoma brucei phosphodiesterase B1 (TbrPDEB1) inhibitor with submicromolar activities against T. brucei parasites. NPD1335 displays a greatly improved cytotoxicity profile. NPD1335 increases intracellular cAMP levels and results in the distortion of the cell cycle and cell death[1].pKi: 6.9 (TbrPDEB1); pIC50: 6.2 (T. brucei) (NPD-1335)[1][1]. de Heuvel E, et al. Alkynamide phthalazinones as a new class of TbrPDEB1 inhibitors (Part 2). Bioorg Med Chem. 2019 Jul 5. pii: S0968-0896(19)30790-4.
特別提醒公司產品僅供科研使用
