產品屬性：
產品名稱 | Lipoxygenin |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y10315 |
Cas No.: 2247911-68-6
別名: N/A
化學名: N/A
分子式: C24H22N2O4
分子量: 402.4
溶解度: DMF: 30mg/mL,DMSO: 30mg/mL,DMSO:PBS (pH 7.2) (1:1): 0.5mg/mL
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Lipoxygenin is an inhibitor of 5-lipoxygenase (5-LO) with an IC50 value of 5 μM for inhibition of 5-LO product synthesis in isolated human granulocytes stimulated with the cation ionophore A23187 .1 It inhibits hedgehog-dependent signaling in Shh-LIGHT2 cells and TGF-β-, activin A-, bone morphogenic protein (BMP)-, or Wnt-dependent signaling in HEK293T cells (IC50s = 9.3, 3.2, 8.2, 9.6, and 3.7 μM, respectively, in luciferase reporter assays). Lipoxygenin (5 and 10 μM) increases levels of troponin T (TnnT), a marker of cardiomyocyte differentiation, in human induced pluripotent stem cells (iPSCs) stimulated with BMP4 and the glycogen synthase kinase 3 (GSK3) inhibitor CHIR99021 . 1.Brand, S., Roy, S., Schr?der, P., et al.Combined proteomic and in silico target identification reveal a role for 5-lipoxygenase in developmental signaling pathwaysCell Chem. Biol.25(9)1095-1106(2018)
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