產品屬性：
產品名稱 | NAE-IN-M22 |
規格 | 5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y10379 |
Cas No.: 864420-54-2
別名: N/A
化學名: N/A
分子式: C20H24Cl2N2
分子量: 363.32
溶解度: DMSO: 250 mg/mL (688.10 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
NAE-IN-M22 is a potent, selective and reversible inhibitor of NEDD8 activating enzyme (NAE), with potency in micromolar range. NAE-IN-M22 inhibits multiple cancer cell lines and induces apoptosis in A549 cells. NAE-IN-M22 also can inhibit tumor growth in vivo[1].M22 (0.37-90 μM; 24 h) blocks neddylation pathway selectively and suppresses degradation of CRL substrates in A549 cells[1].M22 (0.1-100 μM; 48 h) inhibits A549 cell proliferation completely at 30 μM (GI50=5.5 μM, GI90=19.3 μM)[1].M22 (15-30 μM; 36 h) promotes apoptosis in A549 cell line[1].Cell Viability Assay[1] Cell Line:A549 cellsM22 (60 mg/kg; i.p. once daily for 14 d) inhibits tumor growth in nude mice bearing AGS xenografts[1].M22 (0.36-90 μM) has low acute toxicity in zebrafish model[1].[1]. Lu P, et, al. Discovery of a novel NEDD8 Activating Enzyme Inhibitor with Piperidin-4-amine Scaffold by Structure-Based Virtual Screening. ACS Chem Biol. 2016 Jul 15;11(7):1901-7.
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