產品屬性：
產品名稱 | Pantoprazole-d6 |
規格 | 1mg |
貨號 | EY-01Y10445 |
Cas No.: 922727-65-9
別名: N/A
化學名: N/A
分子式: C16H9D6F2N3O4S
分子量: 389.4
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Pantoprazole-d6 is intended for use as an internal standard for the quantification of pantoprazole by GC- or LC-MS. Pantoprazole is a proton pump inhibitor that inhibits H+/K+-ATPase activity in porcine gastric membrane vesicles with an IC50 value of 6.8 μM.1 It reduces basal gastric acid secretion in pylorus-ligated rats (ED50 = 1.3 mg/kg) and inhibits mepirizole-induced increases in gastric acid secretion in an anesthetized rat model of gastric fistula (ED50 = 0.8 mg/kg).2 Pantoprazole inhibits formation of mepirizole-induced duodenal lesions in rats (ED50 = 0.5 mg/kg). Formulations containing pantoprazole have been used in the treatment of gastroesophageal reflux disease (GERD) and hypersecretory conditions, including Zollinger-Ellison Syndrome.References1. Beil, W., Staar, U., and Sewing, K.F. Pantoprazole: A novel H+/K+-ATPase inhibitor with an improved pH stability. Eur. J. Pharmacol. 218(2-3), 265-271 (1992).2. Takeuchi, K., Konaka, A., Nishijima, M., et al. Effects of pantoprazole, a novel H+/K+-ATPase inhibitor, on duodenal ulcerogenic and healing responses in rats: A comparative study with omeprazole and lansoprazole. J. Gastroenterol. Hepatol. 14(3), 251-257 (1999).
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