產品屬性：
產品名稱 | PHY34 |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y10559 |
Cas No.: 2130033-55-3
別名: N/A
化學名: N/A
分子式: C30H30O12
分子量: 582.6
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:3): 0.25 mg/ml,Ethanol: 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PHY34 is an inhibitor of late-stage autophagy.1 It is cytotoxic to OVCAR-3 and OVCAR-8 ovarian cancer cells (IC50 = 4 nM for both) and induces apoptosis in the same cells when used at a concentration of 100 nM. PHY34 increases the number of LC3B puncta and induces autophagosome accumulation in HeLa cells (EC50s = 1.99 and 3.86 nM, respectively). It reduces tumor growth in an OVCAR-8 mouse xenograft model when administered at a dose of 0.75 mg/kg. 1.Young, A.N., Herrera, D., Huntsman, A.C., et al.Phyllanthusmin derivatives induce apoptosis and reduce tumor burden in high-grade serous ovarian cancer by late-stage autophagy inhibitionMol. Cancer Ther.17(10)2123-2135(2018)
特別提醒公司產品僅供科研使用
