產品屬性：
產品名稱 | TG6-129 |
規格 | 500μg、1mg、5mg |
貨號 | EY-01Y10690 |
Cas No.: 1164464-14-5
別名: N/A
化學名: N/A
分子式: C20H18FN5O3S3
分子量: 491.6
溶解度: DMF: 8 mg/ml,DMSO: 10 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Prostaglandin E2 evokes distinct responses through four different 'E prostanoid' (EP) receptors. EP2 is a G protein-coupled receptor that has diverse roles, including those in cancer, inflammation, and neuroprotection. TG6-129 is an antagonist of the EP2 receptor, suppressing PGE2-induced elevation of cAMP in cells expressing EP2 with an IC50 value of 1.6 μM. It is without effect on EP4, DP1, IP, and β2-adrenergic receptors. TG6-129 reduces the expression of COX-2, IL-1β, IL-12, IL-23, IL-6, and TNF-α induced by the EP2-selective agonist butaprost in P388D1 macrophages. It has low cell cytotoxicity (CC50 = 326 μM), prolonged plasma half-life, and does not cross the blood-brain barrier.
特別提醒公司產品僅供科研使用
