產品屬性：
產品名稱 | Ζ-Stat |
規格 | 10mM*1 mL in Water、5 mg、10 mg、50 mg |
貨號 | EY-01Y10669 |
Cas No.: 2/7/3316
別名: N/A
化學名: N/A
分子式: C10H8O10S3
分子量: 384.36
溶解度: H2O : 62.5 mg/mL (162.61 mM; Need ultrasonic)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
ζ-Stat (NSC37044) is a specific and atypical PKC-ζ inhibitor, with an IC50 of 5 μM. ζ-Stat can reduce melanoma cell lines proliferation and induce apoptosis, and has antitumor activity in vitro[1][2].ζ-Stat (0.1-20 μM) shows only 13% inhibition on PKC-Ι at 20 μM, but shows a significant inhibition on PKC-ζ as 51% at 5 μM level[1].ζ-Stat (0.1-10 μM; 3 d) significantly decreases cell proliferation of SK-MEL-2 and MeWo upon increasing the concentrations[1].ζ-Stat (7 or 10 μM; 24-72?h) and 5-FU in combination is able to decrease the viability of LoVo CRC cells by more than 75%[2].ζ-Stat (5 μM; 3 d) shows a significant diminution of phosphorylated, total PKC-ζ, Bcl-2 and PARP levels, and increases Caspase-3 and cleaved-PARP levels in SK-MEL-2 and MeWo cells[1].ζ-Stat (5 μM; 1-10 h) does not show significant cytotoxicity on MEL-F-NEO, SK-MEL-2 and MeWo cells[1].[1]. Ratnayake WS, et, al. Oncogenic PKC-Ι activates Vimentin during epithelial-mesenchymal transition in melanoma; a study based on PKC-Ι and PKC-ζ specific inhibitors. Cell Adh Migr. 2018; 12(5):447-463. [2]. Islam SMA, et, al. Atypical Protein Kinase-C inhibitors exhibit a synergistic effect in facilitating DNA damaging effect of 5-fluorouracil in colorectal cancer cells. Biomed Pharmacother. 2020 Jan; 121:109665.
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