產品屬性：
產品名稱 | Pitstop2 |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y10801 |
Cas No.: 1332879-52-3
別名: N/A
化學名: N-[5-[(4-bromophenyl)methylene]-4,5-dihydro-4-oxo-2-thiazolyl]-1-naphthalenesulfonamide
分子式: C20H13BrN2O3S2
分子量: 473.4
溶解度: 20mg/mL in DMSO
儲存條件: 4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Pitstop2 is an inhibitor of the interaction between the clathrin terminal domain and amphiphysin (IC50 = 12 μM).1 It inhibits clathrin-mediated transferrin uptake in HeLa and U2OS cells (IC50s = 12-15 and 9.7 μM, respectively). Pitstop2 inhibits HIV-1 entry and infectivity in HeLa reporter cell lines. It also inhibits clathrin-independent endocytosis of CD44, CD98, and CD147 in HeLa cells.2
References1. von Kleist, L., Stahlschmidt, W., Bulut, H., et al. Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition. Cell 146(3), 471-484 (2012).2. Dutta, D., Williamson, C.D., Cole, N.B., et al. Pitstop 2 is a potent inhibitor of clathrin-independent endocytosis. PLoS One 7(9), e45799 (2012).
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