產品屬性：
產品名稱 | MD2-TLR4-IN-1 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y10887 |
Cas No.: 2249801-12-3
別名: N/A
化學名: N/A
分子式: C22H14Cl2N4O
分子量: 421.28
溶解度: DMSO: 83.33 mg/mL (197.80 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
MD2-TLR4-IN-1 (compound 22m) is an inhibitor of myeloid differentiation protein 2/toll-like receptor 4 (MD2-TLR4) complex, inhibiting lipopolysaccharides (LPS)-induced expression of tumor necrosis factor alpha (TNF-α) and interleukin-6 (IL-6) in macrophages with IC50 values of 0.89 μM and 0.53 μM, respectively[1].MD2-TLR4[1].[1]. Liu Z, et al. Discovery of 3-(Indol-5-yl)-indazole Derivatives as Novel Myeloid Differentiation Protein 2/Toll-like Receptor 4 Antagonists for Treatment of Acute Lung Injury. J Med Chem. 2019 Jun 13;62(11):5453-5469.
特別提醒公司產品僅供科研使用
