產品屬性：
產品名稱 | N-desmethyl Olanzapine |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y10999 |
Cas No.: 161696-76-0
別名: N/A
化學名: N/A
分子式: C16H18N4S
分子量: 298.4
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,DMSO:PBS (pH 7.2) (1:4): 0.2 mg/ml,Ethanol: 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
N-desmethyl Olanzapine is a major metabolite of the atypical antipsychotic agent olanzapine .1,2 N-desmethyl Olanzapine is formed via oxidative metabolism of olanzapine by the cytochrome 450 (CYP) isoform CYP1A2.11.Ring, B.J., Catlow, J., Lindsay, T.J., et al.Identification of the human cytochromes P450 responsible for the in vitro formation of the major oxidative metabolites of the antipsychotic agent olanzapineJ. Pharmacol. Exp. Ther.276(2)658-666(1996)
2.Chiu, J.A., and Franklin, R.B.Analysis and pharmacokinetics of olanzapine (LY170053) and two metabolites in rat plasma using reversed-phase HPLC with electrochemical detectionJ. Pharm. Biomed. Anal.14(5)609-615(1996)
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