產品屬性：
產品名稱 | L-α-Hydroxyglutaric Acid |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y11046 |
Cas No.: 13095-48-2
別名: 2(S)-HG, 2(S)-Hydroxyglutaric Acid, L-2-HG, L-2-Hydroxyglutaric Acid
化學名: 2S-hydroxy-pentanedioic acid
分子式: C5H8O5
分子量: 148.1
溶解度: 10mg/mL in PBS, pH 7.2
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
L-α-Hydroxyglutaric acid (L-2-HG) is an α-hydroxy acid. It is metabolized to 2-oxoglutarate (α-ketoglutarate) by L-2-hydroxyglutarate dehydrogenase, and mutations in this enzyme lead to 2-hydroxyglutaric aciduria, a neurometabolic disorder characterized by increased L-2-HG levels.[1 ][2] L-2-HG is structurally similar to α-ketoglutarate and competitively inhibits α-ketoglutarate-dependent dioxygenases, including several involved in histone lysine and DNA demethylation.[3][4]
特別提醒公司產品僅供科研使用
