產品屬性：
產品名稱 | MMP-9-IN-1 |
規格 | 5mg、10mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y11179 |
Cas No.: 502887-71-0
別名: N/A
化學名: N/A
分子式: C16H17F2N3O3S
分子量: 369.39
溶解度: DMSO: 125 mg/mL (338.40 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
MMP-9-IN-1 is a specific matrix metalloproteinase-9 (MMP-9) inhibitor, which selectively target the hemopexin (PEX) domain of MMP-9, but not other MMPs[1].MMP-9-IN-1 (compound 2; 100 μM; 14 hours) does not cause notable cytotoxicity[1].MMP-9-IN-1 (compound 2; 10 μM) significantly inhibits cell proliferation of HT-1080 and MDA-MB-435 cells[1].Cell Cytotoxicity Assay[1] Cell Line:COS-1 monkey epithelial cell linesMMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor[1]. MMP-9-IN-1 inhibits cancer cell metastasis in vivo[1].Animal Model:4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor[1][1]. Dufour A, et al. Small-molecule anticancer compounds selectively target the hemopexin domain of matrix metalloproteinase-9. Cancer Res. 2011 Jul 15;71(14):4977-88.
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