產品屬性：
產品名稱 | N-Oleoyl Glutamine |
規格 | 1 mg、5 mg、10 mg、25 mg |
貨號 | EY-01Y11344 |
Cas No.: 247150-73-8
別名: N/A
化學名: N/A
分子式: C23H42N2O4
分子量: 410.6
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
N-Oleoyl glutamine is an endogenous N-acyl amine.1,2 It is both formed and degraded by peptidase M20 domain-containing 1 (PM20D1), a factor secreted by thermogenic adipose cells. N-Oleoyl glutamine (50 μM) induces mitochondrial uncoupling to increase respiration in C2C12 cells by 64%.3 It inhibits capsaicin-induced calcium flux in HEK293A cells co-transfected with transient receptor potential vanilloid 1 (TRPV1) and red fluorescent protein (RFP).2 N-Oleoyl glutamine (100 mg/kg) reduces the number of acetic acid-induced abdominal constrictions, as well as formalin-induced paw licking in mice.1.Long, J.Z., Svensson, K.J., Bateman, L.A., et al.The secreted enzyme PM20D1 regulates lipidated amino acid uncouplers of mitochondriaCell166(2)1-12(2016)
2.Long, J.Z., Roche, A.M., Berdan, C.A., et al.Ablation of PM20D1 reveals N-acyl amino acid control of metabolism and nociceptionProc. Natl. Acad. Sci. U.S.A.115(29)E6937-E6945(2018)
3.Lin, H., Long, J.Z., Roche, A.M., et al.Discovery of hydrolysis-resistant isoindoline N-acyl amino acid analogues that stimulate mitochondrial respirationJ. Med. Chem.61(7)3224-3230(2018)
特別提醒公司產品僅供科研使用
