產品屬性：
產品名稱 | L-Leucyl-L-Leucine methyl ester (hydrochloride) |
規格 | 100mg、250mg、1g |
貨號 | EY-01Y11473 |
Cas No.: 6491-83-4
別名: N/A
化學名: L-leucyl-L-leucine, methyl ester, monohydrochloride
分子式: C13H26N2O3?HCl
分子量: 294.8
溶解度: 30mg/mL in DMSO, 10mg/mL in DMF, 30mg/mL in Ethanol
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
L-Leucyl-L-Leucine methyl ester (LLME) is a lysosomal condensation product that has been reported to be cytotoxic towards natural killer cells and CD4+ and CD8+ T lymphocytes without affecting helper T cells and B cells. [1] [2] It has also been shown to induce death of monocytes, polymorphonuclear leukocytes, and myeloid tumor cells. [2] Upon entry into cells via receptor-mediated endocytosis, LLME undergoes a condensation process catalyzed by dipeptidyl peptidase I (DPPI) in lysosomes. This condensation leads to lysosomal rupture and DNA fragmentation in DPPI-expressing immune cells such as cytotoxic T cells and natural killer cells. [2]
特別提醒公司產品僅供科研使用
