產品屬性：
產品名稱 | p-Ethynylphenylalanine |
規格 | 10mM*1 mL in DMSO、50 mg |
貨號 | EY-01Y11511 |
Cas No.: 278605-15-5
別名: N/A
化學名: N/A
分子式: C11H11NO2
分子量: 189.21
溶解度: DMSO: 2.22 mg/mL (11.73 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
p-Ethynylphenylalanine (4-Ethynyl-L-phenylalanine) is a potent, selective, reversible and competitive inhibitor of tryptophan hydroxylase (TPH), with a Ki of 32.6 μM[1].p-Ethynylphenylalanine selectively and reversibly inhibits the biosynthesis of serotonin[1].p-Ethynylphenylalanine has a low affinity for various recombinant 5-HT receptors (5-HT1, 5-HT2, 5-HT4, 5-HT5, 5-HT6, and 5-HT7)[1].p-Ethynylphenylalanine (30 mg/kg; i.p.) decreases in 5-HT and 5-HIAA levels in the rat midbrain but not in tissue[1].p-Ethynylphenylalanine does not inhibit the aromatic amino acid decarboxylase[1].Animal Model:Male Sprague-Dawley rats (200 g)[1][1]. Stokes AH, et al. p-ethynylphenylalanine: a potent inhibitor of tryptophan hydroxylase. J Neurochem. 2000 May;74(5):2067-73.
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