產品屬性：
產品名稱 | Glp-Amyloid-β (3-40) Peptide (human) (trifluoroacetate salt) |
規(guī)格 | 100μg |
貨號 | EY-01Y12067 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C187H283N51O53S.XCF3COOH
分子量: 4125.7
溶解度: Formic Acid: 1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Glp-Amyloid-β (3-40) peptide is a fragment of amyloid-β (1-40) that contains the cyclic amino acid pyroglutamate at the N-terminus. Glp-Amyloid-β (3-40) peptide is a major component of the endogenous amyloid-β content in post-mortem brain tissue from patients with Alzheimer's disease.1 It is formed through cleavage of the N-terminal aspartate and alanine on Aβ40 and Aβ42 followed by dehydration of glutamic acid by glutaminyl cyclase.2 Glp-Amyloid-β (3-40) peptide has been used as a reference peptide for the quantification of total pyroglutamate amyloid-β in APP23 mouse brain.1References1. Schieb, H., Kratzin, H., Jahn, O., et al. β-Amyloid peptide variants in brains and cerebrospinal fluid from amyloid precursor protein (APP) transgenic mice. Comparison with human Alzheimer amyloid. J. Biol. Chem. 286(39), 33747-33758 (2011).2. Jawhar, S., Wirths, O., and Bayer, T.A. Pyroglutamate amyloid-β (Aβ): A hatchet man in Alzheimer disease. J. Biol. Chem. 286(45), 38825-38832 (2011).
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