產品屬性：
產品名稱 | SR-4835 |
規格 | 10mM*1mL in DMSO、5mg、10mg、25mg、50mg、100mg |
貨號 | EY-01Y12343 |
Cas No.: 2387704-62-1
別名: N/A
化學名: N/A
分子式: C21H20Cl2N10O
分子量: 499.36
溶解度: DMSO: 5 mg/mL (10.01 mM; ultrasonic and warming and heat to 60°C)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
SR-4835 is a potent, highly selective and ATP competitive dual inhibitor of CDK12/CDK13 (CDK12: IC50=99 nM, Kd=98 nM; CDK13: Kd=4.9 nM). SR-4835 acts in synergy with DNA-damaging chemotherapy and PARP inhibitors and provokes triple-negative breast cancer (TNBC) cell death[1].[1]. Quereda V, et al. Therapeutic Targeting of CDK12/CDK13 in Triple-Negative Breast Cancer. Cancer Cell. 2019 Oct 8. pii: S1535-6108(19)30424-6.
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