產品屬性：
產品名稱 | PTC596 |
規格 | 1mg、5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y12375 |
Cas No.: 1610964-64-1
別名: N/A
化學名: N/A
分子式: C19H13F5N6
分子量: 420.34
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PTC596 is an orally active and selective B-cell-specific Moloney murine leukemia virus integration site 1 (BMI-1) inhibitor. PTC596 targets BMI1 expressed by both tumor cells and cancer stem cells (CSCs), and induces hyper-phosphorylation of BMI1, leading to its degradation. PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells[1][2].[1]. Nishida Y, et al. The novel BMI-1 inhibitor PTC596 downregulates MCL-1 and induces p53-independent mitochondrial apoptosis in acute myeloid leukemia progenitor cells. Blood Cancer J. 2017 Feb 17;7(2):e527.
[2]. BMI1 inhibitor PTC596
特別提醒公司產品僅供科研使用
