產品屬性：
產品名稱 | PROTAC Bcl2 degrader-1 |
規格 | 1mg、5mg、10mg、50mg、100mg |
貨號 | EY-01Y12480 |
Cas No.: 2378801-85-3
別名: N/A
化學名: N/A
分子式: C45H45BrN6O10S
分子量: 941.84
溶解度: DMSO: 25 mg/mL (26.54 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PROTAC Bcl2 degrader-1 (Compound C5) is a PROTAC, which potently and selectively induces the degradation of Bcl-2 (IC50, 4.94 μM; DC50, 3.0 μM) and Mcl-1 (IC50, 11.81 μM) by introducing the E3 ligase cereblon (CRBN)-binding ligand pomalidomide to Mcl-1/Bcl-2 dual inhibitor Nap-1[1].[1]. Wang Z, et al. Proteolysis Targeting Chimeras for the Selective Degradation of Mcl-1/Bcl-2 Derived from Nonselective Target Binding Ligands. J Med Chem. 2019 Aug 21.
特別提醒公司產品僅供科研使用
