產品屬性：
產品名稱 | Mcl1-IN-9 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y12495 |
Cas No.: 1810769-31-3
別名: N/A
化學名: N/A
分子式: C37H39ClN4O4
分子量: 639.18
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Mcl1-IN-9 is a potent myeloid cell leukemia-1 (Mcl-1) Inhibitor with an IC50 of 446 nM in reengineered BCR-ABL+ B-ALL cells and a Ki of 0.03 nM[1].
Mcl-1|0.03 nM (Ki)
Mcl1-IN-9 inhibits growth of Mcl-1 dependent tumor cell lines in the nanomolar range[1].Mcl1-IN-9 inhibits the growth of hematological and triple negative breast cancer xenografts at well tolerated doses[1].[1]. Lee T, et al, Discovery of Potent Myeloid Cell Leukemia-1 (Mcl-1) Inhibitors That Demonstrate in Vivo Activity in Mouse Xenograft Models of Human Cancer. J Med Chem. 2019 Apr 25;62(8):3971-3988.
特別提醒公司產品僅供科研使用
