產品屬性：
產品名稱 | Minerval |
規格 | 1mg、5mg、10mg、50mg、100mg |
貨號 | EY-01Y12471 |
Cas No.: 56472-29-8
別名: N/A
化學名: N/A
分子式: C18H34O3
分子量: 298.46
溶解度: Soluble in DMSO
儲存條件: 4°C, protect from light
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Minerval (2-Hydroxyoleic acid) is a synthetic oleic acid (OA) derivative that binds to the plasma membrane and alters lipid organization. Minerval has anti-tumor effect[1].Minerval (25-75 μM; 72 hours) impairs Jurkat cell growth in a time- and concentration-dependent manner, with an IC50 of ~40 μM[1].Minerval (25-50 μM; 72 hours) also induces a marked and concentration-dependent increase in the proteolytic cleavage of PARP, a molecular marker of apoptosis[1].Cell Viability Assay[1] Cell Line:Jurkat cellsMinerval markedly and significantly inhibits tumour growth in nude mice infected with Jurkat cells[1].Animal Model:6-week-old nude male mice (Jurkat cells xenograft model)[1][1]. Llado V, et al. Minerval induces apoptosis in Jurkat and other cancer cells. J Cell Mol Med. 2010 Mar;14(3):659-70.
特別提醒公司產品僅供科研使用
