產品屬性：
產品名稱 | MS023 dihydrochloride |
規格 | Free Sample (0.1-0.5 mg)、10mM*1mL in DMSO、2mg、5mg、10mg、25mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y12568 |
Cas No.: 1992047-64-9
別名: N/A
化學名: N/A
分子式: C17H27Cl2N3O
分子量: 360.32
溶解度: DMSO: ≥ 150 mg/mL (416.30 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
MS023 dihydrochloride is a potent, selective, and cell-active inhibitor of human type I protein arginine methyltransferases (PRMTs) inhibitor, with IC50s of 30, 119, 83, 4 and 5 nM for PRMT1, PRMT3, PRMT4, PRMT6, and PRMT8, respectively[1].IC50: 30 nM (PRMT1), 119 nM (PRMT3), 83 nM (PRMT4), 4 nM (PRMT6), 5 nM (PRMT8)[1]MS023 (1-1000 nM; 48 hours) inhibits PRMT1 methyltransferase activity in MCF7 cells[1]. MS023(1-1000 nM; 20 hours) inhibits PRMT6 methyltransferase activity in HEK293 cells[1].Western Blot Analysis[1] Cell Line:MCF7 and HEK293 cells[1]. Eram MS, et al. A Potent, Selective, and Cell-Active Inhibitor of Human Type I Protein Arginine Methyltransferases. ACS Chem Biol. 2016 Mar 18;11(3):772-81.
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