產品屬性：
產品名稱 | ML-209 |
規格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y12806 |
Cas No.: 1334526-14-5
別名: N/A
化學名: N/A
分子式: C25H31NO6
分子量: 441.5
溶解度: DMSO: 100 mM
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
ML-209 is an antagonist of retinoic acid receptor-related orphan receptor γt (RORγt; IC50 = 1.1 μM in a reporter assay).1 It inhibits RORγt-induced transcription in HEK293T cells expressing the human receptor (IC50 = 300 nM). ML-209 inhibits RORγt-dependent differentiation of isolated na?ve cord blood human CD4+ T cells into Th17 T helper cells.1.Huh, J.R., Englund, E.E., Wang, H., et al.Identification of potent and selective diphenylpropanamide RORγ inhibitorsACS Med. Chem. Lett.4(1)79-84(2013)
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