產品屬性：
產品名稱 | PD 089828 |
規格 | 500μg、1mg、5mg |
貨號 | EY-01Y12871 |
Cas No.: 179343-17-0
別名: N/A
化學名: N/A
分子式: C18H18Cl2N6O
分子量: 405.3
溶解度: DMSO: 25 mg/ml,Ethanol: 1 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PD 089828 is a competitive inhibitor of the receptor tyrosine kinases FGFR1, PDGFRβ, and EGFR (IC50s = 0.15, 1.76, and 5.47 μM, respectively) and a noncompetitive inhibitor of the nonreceptor tyrosine kinase c-Src (IC50 = 0.18 μM). It is selective for these targets over insulin receptor tyrosine kinase, PKC, and CDK4 (IC50s = >50 μM) but does inhibit MAPK (IC50 = 7.1 μM). PD 089828 decreases PDGF-BB-, EGF-, and bFGF-induced phosphorylation of PDGFR, EGFR, and FGFR1, respectively, in a concentration-dependent manner in vitro. It also decreases serum-stimulated growth (IC50 = 1.8 μM after 8 days) and migration (IC50 = 4.5 μM) of rat aortic smooth muscle cells.
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