產品屬性:
產品名稱 | Mutated EGFR-IN-2 |
規格 | 100mg、250mg、500mg |
貨號 | EY-01Y12867 |
Cas No.: 2050906-97-1
別名: N/A
化學名: N/A
分子式: C29H35FN8O3

分子量: 562.64
溶解度: Soluble in DMSO
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述:
Mutated EGFR-IN-2 (compound 91) is a mutant-selective EGFR inhibitor extracted from patent WO2017036263A1, which potently inhibits single-mutant EGFR (T790M) and double-mutant EGFR (including L858R/T790M (IC50=<1nM) and ex19del/T790M), and can suppress activity of single gain-of-function mutant EGFR (including L858R and ex19del) as well. Mutated EGFR-IN-2 shows anti-tumor antivity[1].
EGFRT790M EGFRL858R EGFRex19del EGFR (L858R/T790M)|<1 nM (IC50)|EGFR (ex19del/T790M)
[1]. 2, 4-di-(nitrogen containing group) substituted pyrimidine compound and preparation method and use thereof.
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