產品屬性：
產品名稱 | UNC2541 |
規格 | 10mM*1mL in DMSO、5mg、10mg、25mg、50mg、100mg、200mg |
貨號 | EY-01Y12863 |
Cas No.: 1612782-86-1
別名: N/A
化學名: N/A
分子式: C24H34FN7O2
分子量: 471.57
溶解度: DMSO: 10 mg/mL (21.21 mM; ultrasonic and warming and heat to 60°C)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl, Tyro3 and Flt3. UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].UNC2541 is a potent and Mer tyrosine kinase (MerTK)-specific inhibitor, binds in the MerTK ATP pocket, with an IC50 of 4.4 nM, more selective over Axl (IC50, 120 nM), Tyro3 (IC50, 220 nM) and Flt3 (IC50, 320 nM). UNC2541 inhibits phosphorylated MerTK (pMerTK; EC50, 510 nM)[1].[1]. McIver AL, et al. Discovery of Macrocyclic Pyrimidines as MerTK-Specific Inhibitors. ChemMedChem. 2017 Feb 3;12(3):207-213.
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