產品屬性：
產品名稱 | LDN-91946 |
規格 | 10mM*1 mL in DMSO、10mg、50mg |
貨號 | EY-01Y12935 |
Cas No.: 439946-22-2
別名: N/A
化學名: N/A
分子式: C15H10N2O4S
分子量: 314.32
溶解度: DMSO: 83.33 mg/mL (265.11 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
LDN-91946 is a potent, selective and uncompetitive ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitor with a Ki app of 2.8 μM[1].LDN-91946 is inactive against UCH-L3 at 20 μM. LDN-91946 demonstrates no activity against TGase 2, Papain, and Caspase-3 at 40 μM[1]. There is no cytotoxicity when serum-starved Neuro 2A (N2A) cells are treated with LDN-91946 at concentrations as high as 0.1 mM[1].[1]. Mermerian AH, et al. Structure-activity relationship, kinetic mechanism, and selectivity for a new class of ubiquitin C-terminal hydrolase-L1 (UCH-L1) inhibitors. Bioorg Med Chem Lett. 2007 Jul 1;17(13):3729-32.
特別提醒公司產品僅供科研使用
