產品屬性：
產品名稱 | PluriSIn #2 |
規格 | 5 mg、10 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y13067 |
Cas No.: 56563-17-8
別名: N/A
化學名: N/A
分子式: C11H8FN3O3
分子量: 249.2
溶解度: DMSO: 5 mg/mL (20.06 mM)
儲存條件: 4°C, protect from light, stored under nitrogen
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PluriSIn #2 is a selective transcriptional inhibitor of topoisomerase II α (TOP2A). PluriSIn #2 is a compound that selectively eliminates undifferentiated human pluripotent stem cells (hPSCs)[1].PluriSIn #2 (20 μM; 12 hours) treatment reduces TOP2A expression at the protein level[1].A 24h exposure of PluriSIn #2 (20 μM) is sufficient to induce massive cell death in hPSCs, but doesn't affect the viability of various other cell types derived from them[1].Western Blot Analysis[1] Cell Line:B153 and HUES9 human pluripotent stem cells (hPSCs)[1]. Uri Ben-David, et al. Brief reports: Controlling the survival of human pluripotent stem cells by small molecule-based targeting of topoisomerase II alpha. Stem Cells. 2015 Mar;33(3):1013-9.
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