產品屬性：
產品名稱 | Raloxifene-d4 (hydrochloride) |
規格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y13218 |
Cas No.: 1188263-47-9
別名: N/A
化學名: N/A
分子式: C28H23D4NO4S.HCl
分子量: 514.1
溶解度:
儲存條件: Store at 2°C to 8°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Raloxifene-d4 is intended for use as an internal standard for the quantification of raloxifene by GC- or LC-MS. Raloxifene is a selective estrogen receptor modulator (SERM) that exhibits estrogenic activity in bone cells without stimulating breast or uterine tissues.1 Raloxifene guards endothelial cells obtained from rat aortic rings against oxidative insult (1 μM) and lowers serum cholesterol in ovariectomized rodents (ED50 = 0.2 mg/kg).2,1 Formulations containing raloxifene have been shown to reduce bone resorption and promote bone formation in post-menopausal women.3
1.Black, L.J., Sato, M., Rowley, E.R., et al.Raloxifene (LY139481 HCI) prevents bone loss and reduces serum cholesterol without causing uterine hypertrophy in ovariectomized ratsJ. Clin. Invest.93(1)63-69(1994)
2.Wong, C.M., Yung, L.M., Leung, F.P., et al.Raloxifene protects endothelial cell function against oxidative stressBr. J. Pharmac.155(3)326-334(2008)
3.?zmen, B., Kirmaz, C., Aydin, K., et al.Influence of the selective oestrogen receptor modulator (raloxifene hydrochloride) on IL-6, TNF-α, TGF-?1 and bone turnover markers in the treatment of postmenopausal osteoporosisEur. Cyto. Netw.18(3)148-153(2007)
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