產品屬性：
產品名稱 | Metolazone-d7 |
規格 | 500 μg、1 mg、5 mg |
貨號 | EY-01Y13267 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C16H9D7ClN3O3S
分子量: 372.9
溶解度: DMSO: soluble,Methanol: soluble
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Metolazone-d7 is intended for use as an internal standard for the quantification of metolazone by GC- or LC-MS. Metolazone is a thiazide-like diuretic.1,2 It inhibits the Na+/Cl- cotransporter (IC50 = 0.3 μM for the rat transporter) and human carbonic anhydrase VII (CAVII), CAXII, and CAXIII (Kis = 2.1, 5.4, and 15 nM, respectively). Metolazone (0.3 and 1 mg/kg) induces fluid loss and enhances captopril-induced decreases in blood pressure in spontaneously hypertensive rats.3 Formulations containing metolazone have been used in the treatment of high blood pressure.1.Moreno, E., Cristóbal, P.S., Rivera, M., et al.Affinity-defining domains in the Na-Cl cotransporter: A different location for C- and thiazide bindingJ. Biol. Chem.281(25)17266-17275(2006)
2.Temperini, C., Cecchi, A., Scozzafava, A., et al.Carbonic anhydrase inhibitors. Interaction of indapamide and related diuretics with 12 mammalian isozymes and X-ray crystallographic studies for the indapamide-isozyme II adductBioorg. Med. Chem. Lett.18(8)2567-2573(2008)
3.Chiu, P.J.S., Vemulapalli, S., and Barnett, A.Acute blood pressure and urinary responses to single dose combinations of captopril and diuretics in conscious spontaneously hypertensive ratsJ. Pharm. Pharmacol.37(2)105-109(1985)
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