產品屬性：
產品名稱 | Pramlintide (acetate hydrate) |
規格 | 5mg、10mg、25mg、50mg |
貨號 | EY-01Y13312 |
Cas No.: 196078-30-5
別名: N/A
化學名: N/A
分子式: C171H267N51O53S2?XC2H4O2 [XH2O]
分子量: 3949.4
溶解度: DMSO: 10 mg/ml,PBS (pH 7.2): 5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Pramlintide is a non-amyloidogenic analog of the antidiabetic peptide hormone amylin that contains proline residues substituted at positions 25, 28, and 29. It stimulates cAMP production in HEK293 cells expressing human amylin receptor 1a (AMY1a), AMY2a, and AMY3a (EC50s = 0.35, 22.9, and 0.89 nM, respectively). Pramlintide inhibits human islet amyloid polypeptide fibrilization in a concentration-dependent manner. In vivo, pramlintide (200 pg/kg) reduces brain levels of amyloid-β (1-40) and increases spontaneous alternation in the Y-maze in the Tg2576 transgenic mouse model of Alzheimer's disease.
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