產品屬性：
產品名稱 | ML-290 |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y13378 |
Cas No.: 1482500-76-4
別名: RXFP1 Agonist 8
化學名: 2-[[2-(1-methylethoxy)benzoyl]amino]-N-[3-[(trifluoromethyl)sulfonyl]phenyl]-benzamide
分子式: C24H21F3N2O5S
分子量: 506.5
溶解度: 0.14mg/mL in ethanol, 25mg/mL in DMSO, 30mg/mL in DMF
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
ML-290 is an allosteric agonist of relaxin family peptide receptor 1 (RXFP1; EC50 = 94 nM for human RXFP1).[1],[2] It displays >15-fold selectivity for RXFP1 over RXFP2.[2] ML-290 activates human, rhesus macaque, pig, and rabbit RXFP1 but is weak or inactive at mouse or guinea pig RXFP1.[2],[3] Through RXFP1, ML-290 increases intracellular cAMP and induces VEGF expression (2.8-fold at 250 nM).[2] ML-290 is metabolically stable and displays excellent in vivo pharmacokinetics.[2]
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