產品屬性：
產品名稱 | LTX-315 (trifluoroacetate salt) |
規格 | 5 mg、25 mg、50 mg、100 mg |
貨號 | EY-01Y13373 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C78H106N18O9·XCF3COOH
分子量: 1439.8
溶解度: DMF: 30 mg/ml,DMSO: 30 mg/ml,Ethanol: 1 mg/ml,PBS (pH 7.2): 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
LTX-315 is a synthetic cationic amphiphilic peptide.1 It is cytotoxic to a variety of human cancer cell lines, including A20 lymphoma and AT-84 squamous cell carcinoma cells (IC50s = 8.3 and 11 μM, respectively), and to non-cancerous MRC-5 fibroblasts (IC50 = 34.3 μM) but not human red blood cells (EC50 = >695 μM).2 LTX-315 is also cytotoxic to drug-sensitive and -resistant cancer cell lines (IC50s = 2.1-6.4 and 2.5-3.2 μM, respectively). It permeabilizes mitochondrial membranes and induces immunogenic cell death in tumor cells in vitro.3,1 Intratumoral administration of LTX-315 (1 mg peptide/50 μl saline) increases tumor levels of IL-1β and IL-6 and induces necrosis in, and complete regression of, tumors in a B16/F1 syngeneic mouse model of melanoma.4 1.Zhou, H., Forveille, S., Sauvat, A., et al.The oncolytic peptide LTX-315 triggers immunogenic cell deathCell Death Dis.7(3)e2134(2016)
2.Huag, B.E., Camilo, K.A., Eliassen, L.T., et al.Discovery of a 9-mer cationic peptide (LTX-315) as a potential first in class oncolytic peptideJ. Med. Chem.59(7)2918-2927(2016)
3.Zhou, H., Forveille, S., Sauvat, A., et al.The oncolytic peptide LTX-315 kills cancer cells through Bax/Bak-regulated mitochondrial membrane permeabilizationOncotarget6(29)26599-26614(2015)
4.Camilo, K.A., Berge, G., Ravuri, C.S., et al.Complete regression and systemic protective immune responses obtained in B16 melanomas after treatment with LTX-315Cancer Immunol. Immunother.63(6)601-613(2014)
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