產品屬性：
產品名稱 | MT-802 |
規格 | 1mg、5mg |
貨號 | EY-01Y13528 |
Cas No.: 2231744-29-7
別名: N/A
化學名: N/A
分子式: C41H41N9O8
分子量: 787.82
溶解度: DMSO: 100 mg/mL (126.93 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
MT-802 is a potent BTK degrader based on PROTAC technology, with a DC50 of 1 nM. MT-802 has potential to treat C481S mutant chronic lymphocytic leukemia (CLL)[1].DC50: 1 nM (BTK)[1].MT-802 degrades BTK with a DC50 of 9.1 nM with maximal degradation being observed by 250 nM[1].[1]. Buhimschi AD, et al. Targeting the C481S Ibrutinib-Resistance Mutation in Bruton's Tyrosine Kinase Using PROTAC-Mediated Degradation. Biochemistry. 2018 Jul 3;57(26):3564-3575.
特別提醒公司產品僅供科研使用
