產品屬性：

Cas No.: 173997-05-2

別名: N/A

化學名: N/A

分子式: C14H15F2N3S

分子量: 295.35

溶解度: DMSO: ≥ 48 mg/mL (162.52 mM)

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Nepicastat (SYN117; RS-25560-197) is a dopamine beta-hydroxylase inhibitor with IC50 of 8.5 ± 0.8 and 9.0 ± 0.8 nM for bovine and human, respectively. IC50 value: 8.5/9.0 nM(bovine/human dopamine beta-hydroxylase)Dopamine beta-hydroxylase is an enzyme that catalyzes the conversion of dopamine to norepinephrine. Nepicastat (SYN117; RS-25560-197)   has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated as such.[1]. Stanley WC, et al.   Catecholamine modulatory effects of nepicastat (RS-25560-197), a novel, potent and selective inhibitor of dopamine-beta-hydroxylase.   Br J Pharmacol. 1997 Aug;121(8):1803-9.

  [2]. Stanley WC, et al.   Cardiovascular effects of nepicastat (RS-25560-197), a novel dopamine beta-hydroxylase inhibitor.   J Cardiovasc Pharmacol. 1998 Jun;31(6):963-70.[3]. Sabbah HN, et al.   Effects of dopamine beta-hydroxylase inhibition with nepicastat on the progression of left ventricular dysfunction and remodeling in dogs with chronic heart failure.   Circulation. 2000 Oct 17;102(16):1990-5.

  [4]. Beliaev A, et al.   Synthesis and biological evaluation of novel, peripherally selective chromanyl imidazolethione-based inhibitors of dopamine beta-hydroxylase.   J Med Chem. 2006 Feb 9;49(3):1191-7.
特別提醒公司產品僅供科研使用