產品屬性：
產品名稱 | Mardepodect |
規格 | 10mM*1mL in DMSO、2mg、5mg、10mg、50mg、100mg、200mg、500mg |
貨號 | EY-01Y13797 |
Cas No.: 898562-94-2
別名: N/A
化學名: N/A
分子式: C25H20N4O
分子量: 392.45
溶解度: DMSO: ≥ 45 mg/mL (114.66 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Mardepodect (PF-2545920) is a potent and selective PDE10A inhibitor with an IC50 of 0.37 nM, with >1000-fold selectivity over the PDE.[1]. Verhoest PR, et al. Discovery of a novel class of phosphodiesterase 10A inhibitors and identification of clinical candidate 2-[4-(1-methyl-4-pyridin-4-yl-1H-pyrazol-3-yl)-phenoxymethyl]-quinoline (PF-2545920) for the treatment of schizophrenia. J Med Chem, 2009, 52(16), 5188-5196.
[2]. Grauer SM, et al. Phosphodiesterase 10A inhibitor activity in preclinical models of the positive, cognitive, and negative symptoms of schizophrenia. J Pharmacol Exp Ther, 2009, 331(2), 574-590.
特別提醒公司產品僅供科研使用
