產品屬性：

Cas No.: 1356905-39-9

別名: N/A

化學名: N/A

分子式: C21H26D5N3O5

分子量: 410.5

溶解度: Methanol: soluble,Water: soluble

儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Lisinopril-d5 is intended for use as an internal standard for the quantification of lisinopril by GC- or LC-MS. Lisinopril is an angiotensin-converting enzyme (ACE) inhibitor (IC50 = 1.2 nM).1 It reduces the formation of endothelin-1 and increases nitric oxide in human vascular endothelial cells.2 Lisinopril inhibits the pressor response to angiotensin I in anesthetized rats and dogs (ID50s = 2.3 and 6.5 μg/kg in rat and dog, respectively).1References1. Patchett, A.A., Harris, E., Tristram, E.W., et al. A new class of angiotensin-converting enzyme inhibitors. Nature 288(5788), 280-283 (1980).2. Desideri, G., Grassi, D., Croce, G., et al. Different effects of angiotensin converting enzyme inhibitors on endothelin-1 and nitric oxide balance in human vascular endothelial cells: Evidence of an oxidant-sensitive pathway. Mediators Inflamm. 305087, (2008).
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