產品屬性：
產品名稱 | Noscapine-13C-d3 |
規格 | 500 μg、1 mg |
貨號 | EY-01Y14141 |
Cas No.: 1217680-57-3
別名: N/A
化學名: N/A
分子式: C21[13C]H20D3NO7
分子量: 417.4
溶解度: DMSO: soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Noscapine-13C-d3 is intended for use as an internal standard for the quantification of noscapine by GC- or LC-MS. Noscapine is an alkaloid that has been found in opium and has anticancer and antitussive properties.1,2,3 It binds to tubulin and induces cell cycle arrest at the G2/M phase in HeLa cells when used at a concentration of 20 μM.2 Noscapine induces apoptosis in HeLa cells and thymocytes (IC50s = 25 and 10 μM, respectively) and reduces proliferation of MCF-7 breast and Renal 1983 bladder cancer cells (IC50s = 42.3 and 39.1 μM, respectively). In vivo, noscapine (120 mg/kg) induces tumor regression in an MCF-7 mouse xenograft model. Noscapine (30 and 70 mg/kg) decreases the number of citric acid-induced coughs in guinea pigs.3 1.Kingston, D.G.I.Tubulin-interactive natural products as anticancer agentsJ. Nat. Prod.72(3)507-515(2009)
2.Ye, K., Ke, Y., Keshava, N., et al.Opium alkaloid noscapine is an antitumor agent that arrests metaphase and induces apoptosis in dividing cellsProc. Nat. Acad. Sci. U.S.A.95(4)1601-1606(1998)
3.Idaan-Heikkila, J.E., Jalonen, K., and Vartiainen, A.Evaluation of the antitussive effect of noscapine and codeine on citric acid cough in guinea-pigsActa. Pharmacol. Toxicol. (Copenh)25(3)333-338(1967)
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