產品屬性：
產品名稱 | Norcholic Acid |
規格 | 10 mg、50 mg、100 mg |
貨號 | EY-01Y14247 |
Cas No.: 60696-62-0
別名: N/A
化學名: N/A
分子式: C23H38O5
分子量: 394.5
溶解度: DMSO: slightly soluble,Methanol: slightly soluble
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Norcholic acid is a bile acid and 23-carbon derivative of cholic acid .1 Levels of norcholic acid are increased in the urine of patients with liver cirrhosis or cerebrotendinous xanthomatosis (CTX), an inborn error of metabolism characterized by a deficiency in the mitochondrial enzyme sterol 27-hydrolylase (CYP27A1) that leads to progressive neurological symptoms.2,3,41.Nakatomi, F., Kihira, K., Kuramoto, T., et al.Intestinal absorption and metabolism of norcholic acid in ratsJ. Pharmacobiodyn8(7)557-563(1985)
2.Bremmelgaard, A., and Sj?vall, J.Bile acid profiles in urine of patients with liver diseasesEur. J. Clin. Invest.9(5)341-348(1979)
3.Kuramoto, T., Furukawa, Y., Nishina, T., et al.Identification of short side chain bile acids in urine of patients with cerebrotendinous xanthomatosisJ. Lipid Res.101895-1902(1990)
4.Pilo de la Fuente, B., Sobrido, M.J., Girós, M., et al.Usefulness of cholestanol levels in the diagnosis and follow-up of patients with cerebrotendinous xanthomatosisNeurologia26(7)397-404(2011)
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