產品屬性：
產品名稱 | PTP1B-IN-9 |
規格 | 10mM*1 mL in DMSO、10mg、50mg、100mg |
貨號 | EY-01Y14180 |
Cas No.: 145888-79-5
別名: N/A
化學名: N/A
分子式: C19H13Cl4NO
分子量: 413.12
溶解度: DMSO: 5 mg/mL (12.10 mM)
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
PTP1B-IN-9 is a ubiquitin-proteasome system (UPS)-stressor. PTP1B-IN-9 inhibits ubiquitin-mediated protein degradation upstream of the 20S proteasomal catalytic activites. PTP1B-IN-9 triggers a ubiquitin-proteasome-system (UPS)-stress response without affecting 20S proteasome catalytic activities. Anticancer activity[1].PTP1B-IN-9 (0-30 μM; 48 hours) treatment produces a dose dependent reduction in the viability of HPV16-positive SiHa and Caski cells and HPV-39-positive ME180 cervical cancer cell lines respectively[1].PTP1B-IN-9 reduces the cell viability of exponentially growing HeLa cervical cancer cells in a dose-dependent fashion with an IC50 value of 2 μM[1]. Cell Viability Assay[1] Cell Line:Keratinocytes, SiHa, CaSki and ME180 cells[1]. Anchoori RK, et al. Stressing the ubiquitin-proteasome system without 20S proteolytic inhibition selectively kills cervical cancer cells.PLoS One. 2011;6(8):e23888.
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