產品屬性：
產品名稱 | MCOPPB (hydrochloride hydrate) |
規格 | 1 mg、5 mg、10 mg |
貨號 | EY-01Y14356 |
Cas No.: N/A
別名: N/A
化學名: N/A
分子式: C26H40N4·3HCl [XH2O]
分子量: 536
溶解度: Water: 10 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
The nociceptin/orphanin FQ peptide (NOP, ORL1, or OP4) receptor is a member of the opioid family of receptors that integrates the emotional components of anxiety, fear, and stress. MCOPPB is a potent agonist for the NOP receptor (pKi = 10.1, EC50 = 0.39 nM) with 12-, 270-, and >1,000-fold selectivity over the μ-, κ-, and δ-opioid receptors.1,2 In rodents, MCOPPB at 10 mg/kg, p.o. produces potent anxiolytic effects, without inhibiting memory or motor function or inducing sedative side effects.1 This product is intended for research purposes only.1.Hirao, A., Imai, A., Sugie, Y., et al.Pharmacological characterization of the newly synthesized nociceptin/orphanin FQ-receptor agonist 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole as an anxiolytic agentJournal of Pharmacological Sciences106361-368(2008)
2.Hayashi, S., Hirao, A., Imai, A., et al.Novel non-peptide nociceptin/orphanin FQ receptor agonist, 1-[1-(1-methylcyclooctyl)-4-piperidinyl]-2-[(3R)-3-piperidinyl]-1H-benzimidazole: Design, synthesis, and structure-activity relationship of oral receptor occupancy in the brain for orally potent antianxiety drugJournal of Medicinal Chemistry52610-625(2009)
特別提醒公司產品僅供科研使用
