產品屬性：
產品名稱 | Lornoxicam-d4 |
規格 | 1mg、5mg、10mg |
貨號 | EY-01Y14459 |
Cas No.: 1216527-48-8
別名: N/A
化學名: N/A
分子式: C13H6ClD4N3O4S2
分子量: 375.8
溶解度: DMSO: 2 mg/ml
儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Lornoxicam-d4 is intended for use as an internal standard for the quantification of lornoxicam by GC- or LC-MS. Lornoxicam is a COX inhibitor and non-steroidal anti-inflammatory drug (NSAID) with anti-inflammatory and analgesic properties.1 It inhibits production of thromboxane B2 from arachidonic acid in HEL human erythroleukemic cells (IC50 = 3 nM), which endogenously express COX-1, as well as inhibits LPS-induced formation of prostaglandin F1α from arachidonic acid in Mono-Mac-6 cells (IC50 = 8 nM), which endogenously express COX-2. Lornoxicam reduces LPS-induced production of nitric oxide and IL-6 in cell-based assays with IC50 values of 65 and 54 μM, respectively. It reduces carrageenan-induced paw edema in rats when administered intravenously at doses ranging from 0.1 to 9 mg/kg.2 Formulations containing lornoxicam have been used in the management of postoperative pain.1.Berg, J., Fellier, H., Christoph, T., et al.The analgesic NSAID lornoxicam inhibits cyclooxygenase (COX)-1/-2, inducible nitric oxide synthase (iNOS), and the formation of interleukin (IL)-6 in vitroInflamm. Res.48(7)369-379(1999)
2.Buritova, J., and Besson, J.M.Potent anti-inflammatory/analgesic effects of lornoxicam in comparison to other nsaids: A c-Fos study in the ratInflammopharmacology5(4)331-341(1997)
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