產品屬性：
產品名稱 | Metipranolol (hydrochloride) |
規格 | 1mg、5mg、10mg、25mg |
貨號 | EY-01Y14561 |
Cas No.: 36592-77-5
別名: N/A
化學名: N/A
分子式: C17H27NO4?HCl
分子量: 345.9
溶解度: DMF: 50 mg/ml,DMSO: 50 mg/ml,Ethanol: 10 mg/ml,PBS (pH 7.2): 5 mg/ml
儲存條件: Store at -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.
Shipping ConditionEvaluation sample solution : ship with blue ice
All other available size: ship with RT , or blue ice upon request
產品描述：
Metipranolol is a non-selective β-adrenergic receptor (β-AR) antagonist. It binds to primary rabbit iris and ciliary body homogenates (Ki = 34 nM) and inhibits relaxation induced by isoproterenol in guinea pig atrium and by fenoterol in rat uterus (pA2s = 8.3 and 8.4, respectively). In vitro, metipranolol (100 μM) inhibits anoxia-induced cell death in primary rat retinal cells and sodium nitroprusside-induced lipid peroxidation in rat primary retinal homogenates. In vivo, topical ocular application of metipranolol (0.3%) decreases α-chymotrypsin-induced increases in intraocular pressure (IOP) in rabbits. It also inhibits the blinking response to ocular tactile stimulation in rabbits when administered topically to the eye at a dose of 0.6%. Formulations containing metipranolol have been used in the treatment of elevated IOP in patients with ocular hypertension or glaucoma.
特別提醒公司產品僅供科研使用
