產品屬性：

Cas No.: 84878-61-5

別名: N/A

化學名: N/A

分子式: C47H79O17·NH4

分子量: 934.2

溶解度: DMF: 1 mg/ml

儲存條件: -20°C
General tipsFor obtaining a higher solubility , please warm the tube at 37 ℃ and shake it in the ultrasonic bath for a while.

Shipping ConditionEvaluation sample solution : ship with blue ice

All other available size: ship with RT , or blue ice upon request

產品描述：

Maduramicin is a polyether ionophore antibiotic that has been found in Nocardia.1 It selectively binds to potassium, rubidium, sodium, lithium, and cesium ions over divalent cations. Maduramicin is active against Gram-positive bacteria (MICs = 0.9-125 μg/ml) but not Gram-negative bacteria (MICs = >1,000 μg/ml) or fungi (MICs = 250->1,000 μg/ml). It reduces the viability of asexual and gametocyte P. falciparum parasites (EC50s = 1.3 and 14.8 nM, respectively) and reduces P. berghei transmission in a mouse model of malaria when administered at doses of 4 and 8 mg/kg.2 Maduramicin (5-10 ppm in the diet) reduces the severity of lesions and completely protects chicks against mortality in a model of coccidiosis induced by E. tenella.1 Formulations containing maduramicin have been used in the treatment of coccidiosis in chickens.1.Liu, C.-M., Hermann, T.E., Downey, A., et al.Novel polyether antibiotics X-14868A, B, C, and D produced by a Nocardia. Discovery, fermentation, biological as well as ionophore properties and taxonomy of the producing cultureJ. Antibiot. (Tokyo)36(4)343-350(1983)

2.Maron, M.I., Magle, C.T., Czeny, B., et al.Maduramicin rapidly eliminates malaria parasites and potentiates the gametocytocidal activity of the pyrazoleamide PA21A050Antimicrob. Agents Chemother.60(3)1492-1499(2015)
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